Equis may refer to:

• European Quality Improvement System (or EQUIS), an international system of assessment and accreditation of higher education institutions in management and business administration run by the European Foundation for Management Development
• Equis International (or Equis) a Thomson Reuters software company which produces technical analysis software used in stock markets
• Environmental Quality Information System (or EQuIS) a software package published by EarthSoft, Inc. for analyzing environmental chemistry, geology, limnology, and ancillary data. EQuIS has automated workflow for Electronic Data Deliverable (EDD) management and Esri GIS integration.
• Equis, album by Uruguayan rock band Snake

The EFMD Quality Improvement System (EQUIS) is a school accreditation system. It specializes in higher education institutions of management and business administration, run by the European Foundation for Management Development (EFMD). As of October 2014, EQUIS has accredited 149 business schools in 40 countries around the world.