Hamilton E. Holmes (8 July 1941 – 26 October 1995) was an American orthopedic physician. He and Charlayne Hunter-Gault were the first two African-American students admitted to the University of Georgia. Additionally, Holmes was the first African-American student to attend the Emory University School of Medicine, where he earned his M.D. in 1967, later becoming a professor of orthopedics and associate dean at the school.