"Shake the Disease" is Depeche Mode's thirteenth UK single recorded at Hansa Mischraum in Berlin (released on 29 April 1985), and was one of two new songs released on the compilation The Singles (81-85) the same year, along with "It's Called a Heart". It reached number 18 in the UK singles chart. The American version of The Singles 81-85, Catching Up with Depeche Mode, also includes "Shake the Disease"'s B-side, "Flexible". The track reached the top 40 on the US Billboard Hot Dance Club Play chart in November 1985.