TAME, pronounced tah may, (TAME EP Linea Aerea del Ecuador), is both the flag carrier and the largest airline of Ecuador, with its headquarters located in Quito, Pichincha. Its largest hub is Mariscal Sucre International Airport in Quito.

Tame may refer to:

• Taming, the act of training wild animals
• River Tame, Greater Manchester 
• River Tame, West Midlands and the Tame Valley
• Tame, Arauca, a Colombian town and municipality
• "Tame" (song), a song by the Pixies from their 1989 album Doolittle
• TAME (IATA code: EQ), flag carrier of Ecuador
• tert-Amyl methyl ether, an oxygenated chemical compound often added to gasoline.
• Tame.it, a context search engine for Twitter