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Norepinephrine–dopamine reuptake inhibitor
A
norepinephrine–dopamine reuptake inhibitor
(
NDRI
) is a
drug
that acts as a
reuptake inhibitor
for the
neurotransmitters
norepinephrine
and
dopamine
by blocking the action of the
norepinephrine transporter
(NET) and the
dopamine transporter
(DAT), respectively. This in turn leads to increased
extracellular
concentrations of both norepinephrine and dopamine and, therefore, an increase in
adrenergic
and
dopaminergic
neurotransmission
.
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