In
enzymology,
sarcosine dehydrogenase is a mitochondrial
enzyme that
catalyzes the
chemical reaction N-demethylation of
sarcosine to give
glycine. This enzyme belongs to the family of
oxidoreductases, specifically those acting on the CH-NH group of donor with other acceptors. The systematic name of this enzyme class is
sarcosine:acceptor oxidoreductase (demethylating). Other names in common use include
sarcosine N-demethylase,
monomethylglycine dehydrogenase, and
sarcosine:(acceptor) oxidoreductase (demethylating). Sarcosine dehydrogenase is closely related to
dimethylglycine dehydrogenase, which catalyzes the demethylation reaction of
dimethylglycine to
sarcosine. Both sarcosine dehydrogenase and dimethylglycine dehydrogenase use
FAD as a cofactor. Sarcosine dehydrogenase is linked by
electron-transferring flavoprotein (ETF) to the respiratory redox chain. The general chemical reaction catalyzed by sarcosine dehydrogenase is:
- sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor