Sinus tubercle (also known as
sinual tubercle or
Müllerian eminence) is the proliferation of
endoderm induced by the
paramesonephric ducts. It is located in the developing fetus between the orifices of the
Mesonephric ducts on the
urogenital sinus. The uterovaginal primoridium, which is a fusion of the caudal ends of
paramesonephric ducts, contacts the dorsal wall of the
urogenital sinus and, induces the formation of the sinus tubercle. This occurs in both sexes:
- In the female the mesonephric duct loses all association with the gonad and, disappears. The sinus tubercle then gives rise to the sino-vaginal bulbs and, when it later becomes solid it is referred to as the vaginal plate. It likewise gives rise to the hymen, which eventually breaks down in most cases.
- In the males, the sinus tubercle gives rise to the seminal colliculus.