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Safingol
Safingol
is a lyso-
sphingolipid
protein
kinase
inhibitor
. It has the
molecular formula
C
18
H
39
NO
2
and is a colorless
solid
.
Medicinally
, safingol has demonstrated promising
anticancer
potential as a modulator of multi-
drug resistance
and as an inducer of
necrosis
. The administration of safingol alone has not been shown to exert a significant effect on
tumor
cell
growth
. However, preclinical and clinical studies have shown that combining safingol with conventional
chemotherapy
agents such as
fenretinide
,
vinblastine
,
irinotecan
and
mitomycin C
can dramatically potentiate their antitumor effects. Currently in
Phase I clinical trials
, it is believed to be safe to co-administer with
cisplatin
.
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