The 1995 American League Division Series (ALDS), the opening round of the 1995 American League playoffs, began on Tuesday, October 3, and ended on Sunday, October 8, with the champions of the three AL divisions—along with a "wild card" team—participating in two best-of-five series. As a result of both leagues realigning into three divisions in 1994, it marked the first time in major league history that a team could qualify for postseason play without finishing in first place in its league or division. The teams were:

• (1) Seattle Mariners (Western Division champion, 79–66) vs. (4) New York Yankees (Wild Card, 79–65): Mariners win series, 3–2.
• (2) Boston Red Sox (Eastern Division champion, 86–58) vs. (3) Cleveland Indians (Central Division champion, 100–44): Indians win series, 3–0.