Atsimo-Andrefana is a region of Madagascar. It borders Menabe in north, Amoron'i Mania and Haute Matsiatra in northeast, Ihorombe and Anosy in east and Androy in southeast. The capital is Toliara and the population was estimated to be 1,316,756 in 2013. Atsimo Andrefana is geographically the largest of all Malagasy regions with an area of .