Big Pine (formerly, Bigpine) is a census-designated place (CDP) in Inyo County, California, United States. Big Pine is located approximately south-southeast of Bishop, at an elevation of . The population was 1,756 at the 2010 census, up from 1,350 at the 2000 census. The Big Pine Band of Owens Valley Paiute Shoshone Indians of the Big Pine Reservation operates their tribal headquarters from here.