Cattaraugus Reservation is an Indian reservation of the federally recognized Seneca Nation of Indians, formerly part of the Iroquois Confederacy located in New York. As of the 2000 census, the Indian reservation had a total population of 2,412. Its total area is about 34.4 mi² (89.1 km²). The reservation stretches from Lake Erie inward along Cattaraugus Creek, along either side of NY 438. It is divided among three counties for census purposes:

• Cattaraugus Reservation, Cattaraugus County
• Cattaraugus Reservation, Chautauqua County
• Cattaraugus Reservation, Erie County.