Daphne is a city in Baldwin County, Alabama, United States, on the eastern shoreline of Mobile Bay. The city is located along I-10, 11 miles east of Mobile and 170 miles southwest of the state capital of Montgomery. The 2010 United States Census lists the population of the city as 21,570, making Daphne the most populous city in Baldwin County. It is a principal city of the Daphne-Fairhope-Foley metropolitan area, which includes all of Baldwin County.