Francisco Xavier Sepúlveda (1742 – 1788) was a Mexican colonial soldier and patriarch of the prominent Spanish Mexican Sepúlveda family in the early days of Las Californias and Alta California in present day Southern California, United States. Sepúlveda's eldest son, Juan José Sepúlveda (1764–1808), and his fifth son, Francisco Sepúlveda (1775–1853), became progenitors of two distinguished branches of the family.