The Great Colonnade at Apamea was the main colonnaded avenue of the ancient city of Apamea in the Orontes River valley in northwestern Syria. It was built in the second century CE after Apamea's devastation in the 115 earthquake. The avenue, which ran for nearly , made up the city's north-south axis, or the cardo maximus. The monumental colonnade is among the longest and most famous in the Roman world.