The House of Gonzaga was a princely family that ruled Mantua, in Northern Italy, from 1328 to 1708; they also ruled Monferrato in Piedmont and Nevers in France, and also many other lesser fiefs throughout Europe. Their family includes a saint, twelve cardinals and fourteen bishops. Two Gonzaga descendants became Empresses of the Holy Roman Empire (Eleonora Gonzaga and Eleonora Gonzaga-Nevers), and one became Queen of Polish-Lithuanian Commonwealth (Marie Louise Gonzaga).