Marguerite of Lorraine (22 July 1615 – 13 April 1672), Duchess of Orléans, was the wife of Gaston, younger brother of Louis XIII of France. As Gaston had married her in secret in defiance of the King, Louis had their marriage nullified when it became known. On his deathbed, Louis permitted them to marry. After their remarriage, Marguerite and Gaston had five children. She was the stepmother of La Grande Mademoiselle.