Sheikh Mahdi Al-Khalissi, also known as Mohammad Mahdi Al-Khalissi and Mahdi Al-Khalisi, (died 1925) was a prominent religious leader in Iraq during the British occupation of the early 20th century. At the time he was the Supreme Marja (Shia scholar and spiritual leader) in Iraq. He was also a professor and the head of the College of Divinity at Kadhimiya, Baghdad, Iran.