Osmosis Jones is a 2001 American
live-action/animated buddy cop comedy film directed by
Tom Sito and Piet Kroon for the animated segments and the
Farrelly brothers for the live-action ones. Unusual in this genre, the animated characters are
inside the live-action ones: the film is set in a fictionalized version of the human body which resembles a large
city, where
micro-organisms or any being based in organisms are
anthropomorphic and centers on Frank Detorre, a slovenly
zookeeper. Osmosis Jones, a
white blood cell, teams up with Drix, a
cold pill, against Thrax, a deadly virus who plans to kill Frank in forty-eight hours and other characters living within him.