SAMSON (Software for Adaptive Modeling and Simulation Of Nanosystems) is a software platform for computational nanoscience being developed by the NANO-D group at the French Institute for Research in Computer Science and Automation (INRIA).

Samson (; , meaning "man of the sun"), Shamshoun ( /), or Sampson , is one of the last of the judges of the ancient Israelites mentioned in the Hebrew Bible (Book of Judges chapters 13 to 16).