SIMCA or Simca may refer to:

• Société Industrielle de Mécanique et de Carrosserie Automobile (Simca), a French automobile manufacturer
• Soft independent modelling of class analogies, a statistical method
• Sugud Islands Marine Conservation Area, a Category II Marine Protected Area in Labuk-Sugud District, Malaysia
• Simone Beck, French cookbook author and cooking teacher nicknamed Simca
• Simca, a fictional character in the anime/manga series Air Gear

Simca (, Mechanical and Automotive Body Manufacturing Company) was a French automaker, founded in November 1934 by Fiat and directed from July 1935 to May 1963 by Italian Henri Théodore Pigozzi (born Enrico Teodoro Pigozzi, 1898–1964). Simca was affiliated with Fiat and then, after Simca bought Ford's French activities, became increasingly controlled by the Chrysler Group. In 1970, Simca became a subsidiary and brand of Chrysler Europe, ending its period as an independent company. Simca disappeared in 1978, when Chrysler divested its European operations to another French automaker, PSA Peugeot Citroën. PSA replaced the Simca brand with Talbot after a short period when some models were badged as Simca-Talbots.