St James's is a central district in London in the City of Westminster, forming part of the West End. In the 17th century the area developed as a residential location for the British aristocracy and around the 19th century formed the focus of the development of gentlemen's clubs. Anciently part of the parish of St Martin in the Fields, much of it formed the parish of St James from 1685 to 1922. Since the Second World War the area has transitioned from residential to commercial use.

Saint James or St. James may refer to:

• James (brother of Jesus), also known as 'the Lord's brother', "the Brother of Jesus' or 'James the Just'; considered the author of the Epistle of James in the New Testament, and the first bishop of Jerusalem
• James, son of Zebedee, apostle, brother of John the Apostle, sometimes called "James the Great"
• James, son of Alphaeus, apostle (sometimes identified as 'James the Just')
• James the Less, son of Clopas and Mary of Clopas, often identified with the son of Alphaeus
• Jacob of Nisibis, 4th century bishop
• James Intercisus, 5th century Persian, cut into pieces for expression of his beliefs
• James the Deacon, 7th century missionary to England
• Saint James Matamoros, 8th century Spanish legend
• One of the Ethiopian martyrs Abraham, Ethnus, Acrates, James, and John
• Blessed James Salomoni, Venetian priest and ascetic