The Tyldesley Loopline was part of the London and North Western Railway's Manchester and Wigan Railway line from Eccles to the junction west of Tyldesley station and its continuance south west via Bedford Leigh to Kenyon Junction on the Liverpool and Manchester Railway. The line opened on 1 September 1864 with stations at Worsley, Ellenbrook, Tyldesley, Leigh and Pennington before joining the Liverpool and Manchester Railway at Kenyon Junction.