There are three business routes of US Highway 10 in the state of Michigan. They serve as connections from the main highway into Reed City, Clare and Midland. Additionally, there were another two business routes that connected US Highway 10 (US 10) to the downtowns of Flint and Pontiac. All of these business routes are, or were, former sections of US 10 that were marked Business US Highway 10 (Bus. US 10) after the main highway was realigned to bypass the downtowns of the cities.