U.S. Route 22 (US 22) is a west–east route and is one of the original United States highways of 1926, running from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at U.S. Route 1/9 in the Newark Airport Interchange. US 22 is named the "William Penn Highway" throughout most of Pennsylvania. In southwest Ohio, it overlaps with State Route 3 and is familiarly known as the 3C Highway, "22 and 3", and Montgomery Road.