U.S. Route 22 (
US 22) is a west–east route and is one of the original
United States highways of 1926, running from
Cincinnati, Ohio, at
US 27,
US 42,
US 127, and
US 52 to
Newark, New Jersey, at
U.S. Route 1/9 in the
Newark Airport Interchange. US 22 is named the "
William Penn Highway" throughout most of
Pennsylvania. In southwest
Ohio, it overlaps with
State Route 3 and is familiarly known as the
3C Highway, "22 and 3", and
Montgomery Road.