"Blue Star Memorial Highway (Maryland)" redirects here. See also, U.S. Route 50 in Maryland#Blue Star Memorial Highway

U.S. Route 301 in Maryland is a major highway that runs from Delaware to the Governor Harry W. Nice Memorial Bridge into Virginia. It passes through three of Maryland's four main regions: the Eastern Shore, the Baltimore-Washington Metropolitan Area, and Southern Maryland. US 301 serves mainly as a bypass of Baltimore and Washington from Delaware to Virginia.