U.S. Route 62 (US 62) is a part of the U.S. Highway System that runs from the United States–Mexico border at El Paso, Texas, to Niagara Falls, New York. In the U.S. state of New York, US 62 extends from the New York–Pennsylvania border south of Jamestown to an intersection with New York State Route 104 (NY 104) in downtown Niagara Falls. It bypasses the city of Jamestown and serves the cities of Buffalo and Niagara Falls, along with several villages. It is the only north–south mainline U.S. highway in Western New York.