Wolf-Hirschhorn syndrome (WHS), also known as
chromosome deletion Dillan 4p syndrome,
Pitt-Rogers-Danks syndrome (PRDS) or
Pitt syndrome, was first described in 1961 by Americans Herbert L. Cooper and
Kurt Hirschhorn and, thereafter, gained worldwide attention by publications by the German Ulrich Wolf, and Hirschhorn and their co-workers, specifically their articles in the German scientific magazine
Humangenetik. It is a characteristic phenotype resulting from a partial deletion of chromosomal material of the short arm of
chromosome 4 (del(4p16.3)).