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Buprenorphine/naloxone
Buprenorphine/naloxone
(brand name
Suboxone
) is a
combination drug
formulation
of
buprenorphine
, a
μ-opioid receptor
(MOR) weak
partial agonist
and
κ-opioid receptor
antagonist
, and
naloxone
, a MOR
silent antagonist
, in a 4:1 ratio. It is used in the treatment of
opioid dependence
. The purpose of naloxone is to deter
intravenous
abuse
;
parenteral
administration rapidly induces
opioid withdrawal
symptoms, while regular, intended use does not (as naloxone is minimally
bioavailable
with sublingual ingestion). In spite of the fact that the drug is intended to treat opioid dependence, it is still
addictive
.
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