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5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole
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5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole
5,6-Dichloro-1-ß-
D
-ribofuranosylbenzimidazole
(DRB) is a chemical compound that inhibits transcription elongation by
RNA Polymerase II
. Sensitivity to DRB is dependent on
DRB sensitivity inducing factor
(DSIF),
negative elongation factor
(NELF), and
positive transcription elongation factor b
(P-TEFb). DRB is a
nucleoside
analog and also inhibits some
protein kinases
.
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