The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenousneurotransmitterserotonin (5-hydroxytryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to Gq/G11 and mediates excitatoryneurotransmission. HTR2C denotes the humangene encoding for the receptor, that in humans is located at the X chromosome. As males have one copy of the gene and in females one of the two copies of the gene is repressed, polymorphisms at this receptor can affect the two sexes to differing extent.