Antigonus , a Greek name meaning "comparable to his father" or "worthy of his father", may refer to:
- Three Macedonian kings of the Antigonid dynasty that succeeded Alexander the Great in Asia:
- Antigonus (historian), a Greek writer on history
- Antigonus of Alexandria, ancient Greek grammarian
- Antigonus of Cumae, ancient Greek writer on agriculture
- Antigonus, a writer on painting, mentioned by Diogenes Laërtius, is perhaps the same as the sculptor with this name, whom we know to have written on statuary.
- Antigonus, a general of Perseus in the war with the Romans, was sent to Aenia to guard the coast.
- Antigonus (sculptor), a Greek statuary
- Antigonus (physician), an ancient Greek surgeon
- Antigonos (son of Callas) Macedonian hetairos and athlete
- Antigonus of Carystus, 3rd century BC Greek writer on various subjects
- Antigonus of Sokho, Jewish scholar of the third century BC.
- Antigonus II Mattathias (died 37 BC), the last ruler of the Hasmonean kingdom of Judea
- Antigonus (butterfly), a genus of skipper butterflies