Antigonus , a Greek name meaning "comparable to his father" or "worthy of his father", may refer to:

• Three Macedonian kings of the Antigonid dynasty that succeeded Alexander the Great in Asia:
  • Antigonus I Monophthalmus (382–301 BC)
  • Antigonus II Gonatas (319–239 BC)
  • Antigonus III Doson (263–221 BC)
    • Antigonus, son of Echecrates, the brother of Antigonus III Doson
• Antigonus (historian), a Greek writer on history
• Antigonus of Alexandria, ancient Greek grammarian
• Antigonus of Cumae, ancient Greek writer on agriculture
• Antigonus, a writer on painting, mentioned by Diogenes Laërtius, is perhaps the same as the sculptor with this name, whom we know to have written on statuary.
• Antigonus, a general of Perseus in the war with the Romans, was sent to Aenia to guard the coast.
• Antigonus (sculptor), a Greek statuary
• Antigonus (physician), an ancient Greek surgeon
• Antigonos (son of Callas) Macedonian hetairos and athlete
• Antigonus of Carystus, 3rd century BC Greek writer on various subjects
• Antigonus of Sokho, Jewish scholar of the third century BC.
• Antigonus II Mattathias (died 37 BC), the last ruler of the Hasmonean kingdom of Judea
• Antigonus (butterfly), a genus of skipper butterflies