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Additional
Catabolite activator protein
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Catabolite activator protein
Catabolite Activator Protein
(CAP; also known as
cAMP receptor protein
,
CRP
) is a
transcriptional activator
that exists as a
homodimer
in solution, with each subunit comprising a
ligand
-binding domain at the
N-terminus
(CAP
N
, residues 1-138), which is also responsible for the dimerization of the protein, and a
DNA-binding domain
at the
C-terminus
(DBD, residues 139-209). Two cAMP (
cyclic AMP
) molecules bind dimeric CAP with negative
cooperativity
and function as
allosteric
effectors by increasing the protein's
affinity
for
DNA
.
Cytosolic
cAMP levels rise when the amount of
glucose
transported into the cell is low.
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