Greek National Road 48 (, abbreviated as EO48) is a single carriageway road in central Greece. It connects the Greek National Road 5 at Antirrio with the town Livadeia, passing through Naupactus and Delphi. The section between  Antirrio and Itea is part of European route E65. The GR-48 passes through the regional units Aetolia-Acarnania, Phocis and Boeotia.