Greensboro (formerly Greensborough) is a city in the U.S. state of North Carolina. It is the third-largest city by population in North Carolina and the largest city in Guilford County and the surrounding Piedmont Triad metropolitan region. According to the 2012 U.S. Census Estimate, Greensboro's population is 277,080. It is located at the intersection of three major interstate highways (Interstate 85, Interstate 40 and Interstate 73) in the Piedmont region of central North Carolina.