The Knik River is a 25-mile-long (40 km) river in the U.S. state of Alaska. Its source is at Knik Glacier, from which it flows northwest and west and empties into the head of Cook Inlet's Knik Arm, near the mouth of the Matanuska River. It is bridged twice (old and new bridges) where the Old Glenn Highway crosses it near the Butte, and also bridged on the Hayflats.