The Kvichak River is a large river, about long, in southwestern Alaska in the United States. It flows southwest from Lake Iliamna to Kvichak Bay, an arm of Bristol Bay, on the Alaska Peninsula. The communities of Igiugig and Levelock lie along the Kvichak River. The Kvichak is navigable along its entire length, and is used as a short cut by boats getting between Cook Inlet and Bristol Bay via the Lake Iliamna portage.