Manuel Antonio Pérez Sánchez (July 12, 1900 – January 28, 1930), better known as Manuel Antonio, was a Galician poet. He was honoured on Galician Literature Day in 1979.

Manuel António Leitão da Silva (born 29 January 1946 in Santo Tirso, Porto), known as Manuel António, is a Portuguese retired footballer who played as a striker.

Manuel Antonio National Park, in Spanish the Parque Nacional Manuel Antonio, is a small National Park in the Central Pacific Conservation Area located on the Pacific coast of Costa Rica, just south of the city of Quepos, Puntarenas, and from the national capital of San José. Established in 1972 with a land area enumerating 1 983 ha (the smallest of any Costa Rican national park), it is the destination of as many as 150,000 visitors annually and well known for its beautiful beaches and hiking trails. In 2011, Manuel Antonio was listed by Forbes among the world's 12 most beautiful national parks.