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Anaplasia
Anaplasia
(from
ancient Greek
: ἀνά
ana
, "backward" + πλάσις
plasis
, "formation") is a condition of
cells
in which they have poor
cellular differentiation
, losing the
morphological
characteristics of mature cells and their orientation with respect to each other and to
endothelial
cells. The term also refers to a group of morphological changes in a cell (nuclear
pleomorphism
, altered
nuclear-cytoplasmic ratio
, presence of
nucleoli
, high proliferation index) that point to a possible
malignant transformation
.
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