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Additional
collectin
English Wikipedia - The Free Encyclopedia
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Collectin
Collectins
(
collagen-containing C-type lectins
) are a part of the
innate immune system
. They form a family of collagenous Ca
2+
-dependent defense
lectins
, which are found in animals. Collectins are soluble
pattern recognition receptors
(PRRs). Their function is to bind to oligosaccharide structure or lipids which are on the surface of microorganisms. Like other PRRs they bind
pathogen-associated molecular patterns
(PAMPs) and also
danger-associated molecular patterns
(DAMPs) of oligosaccharide origin. Binding of collectins to microorganisms may trigger elimination of microorganisms by
aggregation
,
complement
activation,
opsonization
, activation of
phagocytosis
or inhibition of microbial growth. Other functions of collectins are modulation of
inflammatory
,
allergic responses
,
adaptive immune system
and clearance of apoptotic cells.
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