Interleukin-10 (
IL-10), also known as
human cytokine synthesis inhibitory factor (
CSIF), is an anti-
inflammatory cytokine. In humans, IL-10 is encoded by the
IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor 2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.