The minor actinides are the actinide elements in used nuclear fuel other than uranium and plutonium, which are termed the major actinides. The minor actinides include neptunium, americium, curium, berkelium, californium, einsteinium, and fermium. The most important isotopes in spent nuclear fuel are neptunium-237, americium-241, americium-243, curium-242 through -248, and californium-249 through -252.