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PCNT
Pericentrin (kendrin)
, also known as
PCNT
and pericentrin-B (PCNTB), is a
protein
which in humans is encoded by the
PCNT
gene
on chromosome 21. This protein
localizes
to the
centrosome
and recruits proteins to the
pericentriolar matrix
(PCM) to ensure proper centrosome and
mitotic spindle
formation, and thus, uninterrupted
cell cycle
progression. This gene is implicated in many
diseases
and
disorder
s, including
congenital disorders
such as
microcephalic osteodysplastic primordial dwarfism type II
(MOPDII) and
Seckel syndrome
.
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