The Caloosahatchee River is a river on the southwest Gulf Coast of Florida in the United States, approximately long. It drains rural areas on the northern edge of the Everglades, east of Fort Myers. An important link in the Okeechobee Waterway, a manmade inland waterway system of southern Florida, the river forms a tidal estuary along most of its course and has recently become the subject of efforts to restore and preserve the Everglades.