Chenzhou is a city located in the south of Hunan province, People's Republic of China. Its administrative area covers , 9.2% of the provincial area, and its total population reached 4,559,600 in 2001, 26% of them living in urban areas, 74% of them live in rural areas.

Chenzhou or Chen Prefecture (陳州) was a zhou (prefecture) in imperial China seated in modern Huaiyang County, Henan, China. It existed (intermittently) from the 6th century to 1913.