See David Holmes (disambiguation) for other persons with this name.

David L. "Dave" Holmes (January 7, 1924 – August 25, 1999) was an American football player and coach. He was the head coach at Eastern Washington State College, now Eastern Washington University, from 1963 to 1967, where his record was 34–13–1. Holmes then went on to the University of Hawaii (1968–1973), where he still holds the record for highest career winning percentage (.718). Under Holmes, Hawaii never had a losing season. Holmes was a graduate of Tonasket High School and Whitworth College in Spokane, Washington. Holmes began and ended his head coaching career as a high school coach in Spokane. Prior to his tenure at Eastern Washington, he was the head coach at North Central High School, where he compiled a 35–28–4 record. Holmes finished his coaching career at University High School. His record at University was 60–38–3 from 1974 to 1984. His career prep record was 95–66–7. Holmes died on August 25, 1999 at the age of 75 of an apparent heart attack while fly fishing in Northern Idaho.