David S. Eisenberg (born 15 March 1939) is an American biochemist and biophysicist best known for his contributions to structural biology and computational molecular biology. A professor at the University of California, Los Angeles since the early 1970s and director of the UCLA-DOE Institute for Genomics & Proteomics since the early 1990s, as well as a member of the California NanoSystems Institute (CNSI) at UCLA.