Fear and Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream is a novel by Hunter S. Thompson, illustrated by Ralph Steadman. The book is a roman à clef, rooted in autobiographical incidents. The story follows its protagonist, Raoul Duke, and his attorney, Dr. Gonzo, as they descend on Las Vegas to chase the American Dream through a drug-induced haze, all the while ruminating on the failure of the 1960s countercultural movement. The work is Thompson's most famous, and is noted for its lurid descriptions of illegal drug use, its early retrospective on the culture of the 1960s, and its popularization of Thompson's highly subjective blend of fact and fiction that has become known as gonzo journalism. The novel first appeared as a two-part series in Rolling Stone magazine in 1971, was published as a book in 1972, and was later adapted into a film of the same name in 1998 by Terry Gilliam, starring Johnny Depp and Benicio del Toro who portrayed Raoul Duke and Dr. Gonzo, respectively.

Fear, and Loathing in Las Vegas (sometimes stylized Fear & Loathing in Las Vegas or Fear N' Loathing in Las Vegas) is a Japanese electronicore/grindcore/digital hardcore band from Kobe, Hyogo Prefecture, formed in summer 2008.