Florence (O'odham: S-auppag) is a town, sixty-one miles southeast of Phoenix, in the  Pinal County of Arizona, United States. Florence, which is the county seat of Pinal County, is one of the oldest towns in that county and is regarded as a National Historic District with over 25 buildings listed on the National Register of Historic Places. The population of Florence was 25,536 at the 2010 census.